Towards Prebiotic Catalytic Amyloids Using High Throughput Screening
نویسندگان
چکیده
منابع مشابه
Towards Prebiotic Catalytic Amyloids Using High Throughput Screening
Enzymes are capable of directing complex stereospecific transformations and of accelerating reaction rates many orders of magnitude. As even the simplest known enzymes comprise thousands of atoms, the question arises as to how such exquisite catalysts evolved. A logical predecessor would be shorter peptides, but they lack the defined structure and size that are apparently necessary for enzyme f...
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High-throughput screening (HTS) using model organisms is a promising method to identify a small number of genes or drugs potentially relevant to human biology or disease. In HTS experiments, robots and computers do a significant portion of the experimental work. However, one remaining major bottleneck is the manual analysis of experimental results, which is commonly in the form of microscopy im...
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Methods capable of exhaustively screening for crystal polymorphism remain an elusive goal in solid-state chemistry. Particularly promising among the new generation of approaches is polymer-induced heteronucleation (PIHn), a tool utilizing hundreds of unique polymers for granting kinetic access to polymorphs. Here PIHn is redeployed in a high density format in which 288 distinct polymers, each a...
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We are investigating the use of spherical harmonic (SH) expansions as an efficient way to represent and compare small ligand molecules for high throughput virtual screening (HTVS). It has been shown previously that SH expansions are well suited to calculating rotational correlations to superpose similar molecular surfaces1 and dock complementary protein shapes2. It has also been shown that SHs ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2015
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0143948